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1

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

Akbar, Arne N., Henson, Sian M., Lanna, Alessio

Journal:

Trends in Immunology

Année:

2016

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2016

2

The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis

Mike Salmon, Darrell Pilling, Nicola J. Borthwick, Nick Viner, George Janossy, Paul A. Bacon, Arne N. Akbar

Journal:

European Journal of Immunology

Année:

1994

Langue:

english

Fichier:

PDF, 902 KB

english, 1994

3

Using hash tables to manage the time-storage complexity in a point location problem: Application to explicit model predictive control

Farhad Bayat, Tor Arne Johansen, Ali Akbar Jalali

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 543 KB

english, 2011

4

Human immunosenescence: is it infectious?

Graham Pawelec, Arne Akbar, Calogero Caruso, Rafael Solana, Beatrix Grubeck-Loebenstein, Anders Wikby

Journal:

Immunological Reviews

Année:

2005

Langue:

english

Fichier:

PDF, 129 KB

english, 2005

5

Regulatory T cells in human disease and their potential for therapeutic manipulation

Leonie S. Taams, Donald B. Palmer, Arne N. Akbar, Douglas S. Robinson, Zarin Brown, Catherine M. Hawrylowicz

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 145 KB

english, 2006

6

10.1038/17409

Salmon, Mike, Buckley, Christopher D., Pilling, Darrell, Henriquez, Nick V., Parsonage, Greg, Threlfall, Katy, Scheel-Toellner, Dagmar, Simmons, David L., Akbar, Arne N., Lord, Janet M.

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 413 KB

english, 1999

7

10.1038/17416

Salmon, Mike, Buckley, Christopher D., Pilling, Darrell, Henriquez, Nick V., Parsonage, Greg, Threlfall, Katy, Scheel-Toellner, Dagmar, Simmons, David L., Akbar, Arne N., Lord, Janet M.

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 232 KB

english, 1999

8

Immune responses in the skin in old age

Milica Vukmanovic-Stejic, Malcolm HA Rustin, Janko Nikolich-Zugich, Arne N Akbar

Journal:

Current Opinion in Immunology

Année:

2011

Langue:

english

Fichier:

PDF, 160 KB

english, 2011

9

Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells

Leonie S. Taams, Jocea M.R. van Amelsfort, Machteld M. Tiemessen, Kim M.G. Jacobs, Esther C. de Jong, Arne N. Akbar, Johannes W.J. Bijlsma, Floris P.J.G. Lafeber

Journal:

Human Immunology

Année:

2005

Langue:

english

Fichier:

PDF, 228 KB

english, 2005

10

CD4+ T-lymphocyte telomere length is related to fibrosis stage, clinical outcome and treatment response in chronic hepatitis C virus infection

Matthew Hoare, William T.H. Gelson, Abhi Das, Jean M. Fletcher, Susan E. Davies, Martin D. Curran, Sarah L. Vowler, Mala K. Maini, Arne N. Akbar, Graeme J.M. Alexander

Journal:

Journal of Hepatology

Année:

2010

Langue:

english

Fichier:

PDF, 941 KB

english, 2010

11

5125963 Metallurgical controlling method

Sansoni, Paolo, Vescovini, Rosanna, Fagnoni, Francesco F., Akbar, Arne, Arens, Ramon, Chiu, Yen-Ling, Čičin-Šain, Luka, Dechanet-Merville, Julie, Derhovanessian, Evelyna, Ferrando-Martinez, Sara, Fran

Journal:

Minerals Engineering

Année:

1993

Langue:

english

Fichier:

PDF, 67 KB

english, 1993

12

10.1038/7827

Kipling, David, Wynford-Thomas, David, Jones, Chris J., Akbar, Arne, Aspinall, Richard, Bacchetti, Silvia, Blasco, Maria A., Broccoli, Dominique, DePinho, Ron A., Edwards, Dylan R., Effros, Rita B., H

Journal:

Nature Biotechnology

Année:

1999

Langue:

english

Fichier:

PDF, 88 KB

english, 1999

13

The Convergence of Senescence and Nutrient Sensing During Lymphocyte Ageing

Journal:

Clinical & Experimental Immunology

Année:

2016

Langue:

english

Fichier:

PDF, 604 KB

english, 2016

14

The global response to the COVID-19 pandemic: how have immunology societies contributed?

Osier, Faith, Ting, Jenny P. Y., Fraser, John, Lambrecht, Bart N., Romano, Marta, Gazzinelli, Ricardo T., Bortoluci, Karina R., Zamboni, Dario S., Akbar, Arne N., Evans, Jennie, Brown, Doug E., Patel,

Journal:

Nature Reviews Immunology

Année:

2020

Fichier:

PDF, 1.34 MB

2020

15

Follicular dendritic cells share a membrane-bound protein with fibroblasts

Bofill, Margarita, Akbar, Arne N., Amlot, Peter L.

Journal:

The Journal of Pathology

Année:

2000

Langue:

english

Fichier:

PDF, 694 KB

english, 2000

16

Interferon-β mediates stromal cell rescue of T cells from apoptosis

Darrell Pilling, Arne N. Akbar, John Girdlestone, Catherine H. Orteu, Nicola J. Borthwick, Nicole Amft, Dagmar Scheel-Toellner, Christopher D. Buckley, Mike Salmon

Journal:

European Journal of Immunology

Année:

1999

Langue:

english

Fichier:

PDF, 175 KB

english, 1999

17

Inhibition of T cell apoptosis by IFN-β rapidly reverses nuclear translocation of protein kinase C-δ

Dagmar Scheel-Toellner, Darrell Pilling, Arne N. Akbar, Deborah Hardie, Giovanna Lombardi, Mike Salmon, Janet M. Lord

Journal:

European Journal of Immunology

Année:

1999

Langue:

english

Fichier:

PDF, 176 KB

english, 1999

18

Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population

Leonie S. Taams, Jay Smith, Malcolm H. Rustin, Mike Salmon, Len W. Poulter, Arne N. Akbar

Journal:

European Journal of Immunology

Année:

2001

Langue:

english

Fichier:

PDF, 197 KB

english, 2001

19

Cytokine-mediated inhibition of apoptosis in non-transformed T cells and neutrophils can be dissociated from protein kinase B activation

Dagmar Scheel-Toellner, Keqing Wang, Nico V. Henriquez, Paul R. Webb, Rachel Craddock, Darrell Pilling, Arne N. Akbar, Mike Salmon, Janet M. Lord

Journal:

European Journal of Immunology

Année:

2002

Langue:

english

Fichier:

PDF, 175 KB

english, 2002

20

Subpopulations of primed t helper cells in rheumatoid arthritis

Nick Matthews, Paul Emery, Darrell Pilling, Arne Akbar, Mike Salmon

Journal:

Arthritis & Rheumatism

Année:

1993

Langue:

english

Fichier:

PDF, 446 KB

english, 1993

21

Reply

Mike Salmon, Darrell Pilling, Arne N. Akbar, Paul Emery

Journal:

Arthritis & Rheumatism

Année:

1994

Langue:

english

Fichier:

PDF, 127 KB

english, 1994

22

Human CD4+CD45RO+ and CD4+CD45RA+ T cells synergize in response to alloantigens

Arne N. Akbar, Michael Salmon, Kamal Ivory, Shinsuke Taki, Darrell Pilling, George Janossy

Journal:

European Journal of Immunology

Année:

1991

Langue:

english

Fichier:

PDF, 691 KB

english, 1991

23

Interleukin-2 receptor common γ-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression

Arne N. Akbar, Nicola J. Borthwick, R. Gitendra Wickremasinghe, Panayiotis Panayiotidis, Darrell Pilling, Margarita Bofill, Stanislaw Krajewski, John C. Reed, Mike Salmon

Journal:

European Journal of Immunology

Année:

1996

Langue:

english

Fichier:

PDF, 659 KB

english, 1996

24

Features of immune senescence in liver transplant recipients with established grafts

William Gelson, Matthew Hoare, Sarah Vowler, Arun Shankar, Paul Gibbs, Arne N. Akbar, Graeme J. M. Alexander

Journal:

Liver Transplantation

Année:

2010

Langue:

english

Fichier:

PDF, 206 KB

english, 2010

25

The synergy between naive and memory T cells during activation

Arne N. Akbar, Michael Salmon, George Janossy

Journal:

Immunology Today

Année:

1991

Langue:

english

Fichier:

PDF, 613 KB

english, 1991

26

A possible role for bcl-2 in regulating T-cell memory - a ‘balancing act’ between cell death and survival

Arne N. Akbar, Michael Salmon, John Savill, George Janossy

Journal:

Immunology Today

Année:

1993

Langue:

english

Fichier:

PDF, 696 KB

english, 1993

27

Memory T cell homeostasis and senescence during aging

Arne N Akbar, Jean M Fletcher

Journal:

Current Opinion in Immunology

Année:

2005

Langue:

english

Fichier:

PDF, 318 KB

english, 2005

28

Significance of senescence for virus-specific memory T cell responses: rapid ageing during chronic stimulation of the immune system

Debbie van Baarle, Aster Tsegaye, Frank Miedema, Arne Akbar

Journal:

Immunology Letters

Année:

2005

Langue:

english

Fichier:

PDF, 428 KB

english, 2005

29

Mantoux Test as a model for a secondary immune response in humans

Milica Vukmanovic-Stejic, John R. Reed, Katie E. Lacy, Malcolm H.A. Rustin, Arne N. Akbar

Journal:

Immunology Letters

Année:

2006

Langue:

english

Fichier:

PDF, 630 KB

english, 2006

30

Loss of CD28 expression differentiates memory and effector CD8+ T cells

Nicola J. Borthwick, Helena Hyde, Mark Lowdell, Imad Hassan, Mike Salmon, Arne N. Akbar

Journal:

Immunology Letters

Année:

1997

Langue:

english

Fichier:

PDF, 185 KB

english, 1997

31

IFN-α and IFN-β: a link between immune memory and chronic inflammation

Arne N Akbar, Janet M Lord, Mike Salmon

Journal:

Immunology Today

Année:

2000

Langue:

english

Fichier:

PDF, 195 KB

english, 2000

32

Cellular environments and apoptosis: tissue microenvironments control activated T-cell death

Arne N. Akbar, Mike Salmon

Journal:

Immunology Today

Année:

1997

Langue:

english

Fichier:

PDF, 545 KB

english, 1997

33

The peripheral generation of CD4+ CD25+ regulatory T cells

Arne N. Akbar, Leonie S. Taams, Mike Salmon, Milica Vukmanovic-Stejic

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 115 KB

english, 2003

34

Immunosenescence and Cytomegalovirus: where do we stand after a decade?

Graham Pawelec, Arne Akbar, Peter Beverley, Calogero Caruso, Evelyna Derhovanessian, Tamas Fülöp, Paul Griffiths, Beatrix Grubeck-Loebenstein, Klaus Hamprecht, Gerhard Jahn, Florian Kern, Sven D Koch,

Journal:

Immunity & Ageing

Année:

2010

Langue:

english

Fichier:

PDF, 173 KB

english, 2010

35

Report from the second cytomegalovirus and immunosenescence workshop

Mark Wills, Arne Akbar, Mark Beswick, Jos A Bosch, Calogero Caruso, Giuseppina Colonna-Romano, Ambarish Dutta, Claudio Franceschi, Tamas Fulop, Effrossyni Gkrania-Klotsas, Joerg Goronzy, Stephen J Gri

Journal:

Immunity & Ageing

Année:

2011

Langue:

english

Fichier:

PDF, 176 KB

english, 2011

36

Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis

Dagmar Scheel-Toellner, Karim Raza, Lakhvir Assi, Darrell Pilling, Emma J. Ross, Wing Yiu Lee, S. John Curnow, Christopher D. Buckley, Arne N. Akbar, Janet M. Lord, Mike Salmon

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 374 KB

english, 2008

37

KLRG1—more than a marker for T cell senescence

Sian M. Henson, Arne N. Akbar

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 207 KB

english, 2009

38

Patients with B cell chronic lymphocytic leukaemia have an expanded population of CD4+ perforin expressing T cells enriched for human cytomegalovirus specificity and an effector-memory phenotype

James A. Walton, Peter M. Lydyard, Amit Nathwani, Vincent Emery, Arne Akbar, Martin J. Glennie, Nino Porakishvili

Journal:

British Journal of Haematology

Année:

2010

Langue:

english

Fichier:

PDF, 445 KB

english, 2010

39

Prolonged exposure of naïve CD8+ T cells to interleukin-7 or interleukin-15 stimulates proliferation without differentiation or loss of telomere length

Diana L. Wallace, Marion Bérard, Maria V. D. Soares, Janine Oldham, Joanne E. Cook, Arne N. Akbar, David F. Tough, Peter C. L. Beverley

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 988 KB

english, 2006

40

Human cytomegalovirus-specific CD8+ T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects

Diana L. Wallace, Joanne E. Masters, Catherine M. de Lara, Sian M. Henson, Andrew Worth, Yan Zhang, Shikha R. Kumar, Peter C. Beverley, Arne N. Akbar, Derek C. Macallan

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 446 KB

english, 2011

41

Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade

Sian M. Henson, Richard Macaulay, Ornella Franzese, Arne N. Akbar

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 320 KB

english, 2012

42

Opinion: Will telomere erosion lead to a loss of T-cell memory?

Akbar, Arne N., Beverley, Peter C. L., Salmon, Mike

Journal:

Nature Reviews Immunology

Année:

2004

Langue:

english

Fichier:

PDF, 202 KB

english, 2004

43

The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery

Akbar, Arne N., Vukmanovic-Stejic, Milica, Taams, Leonie S., Macallan, Derek C.

Journal:

Nature Reviews Immunology

Année:

2007

Langue:

english

Fichier:

PDF, 372 KB

english, 2007

44

Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?

Akbar, Arne N., Henson, Sian M.

Journal:

Nature Reviews Immunology

Année:

2011

Langue:

english

Fichier:

PDF, 544 KB

english, 2011

45

Herbimycin A accelerates the induction of apoptosis following etoposide treatment or γ-irradiation of bcr/abl-positive leukaemia cells

Riordan, Fiona A, Bravery, Christopher A, Mengubas, Kamuran, Ray, Nandita, Borthwick, Nicola J, Akbar, Arne N, Hart, Steven M, Hoffbrand, A Victor, Mehta, Atul B, Wickremasinghe, R Gitendra

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 609 KB

english, 1998

46

Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily

Giuseppina Colonna-Romano, Arne N. Akbar, Alessandra Aquino, Matteo Bulati, Giuseppina Candore, Domenico Lio, Pietro Ammatuna, Jean M. Fletcher, Calogero Caruso, Graham Pawelec

Journal:

Experimental Gerontology

Année:

2007

Langue:

english

Fichier:

PDF, 196 KB

english, 2007

47

Differential regulation of CD8+ T cell senescence in mice and men

Arne N Akbar, Maria Vieira D Soares, Fiona J Plunkett, Mike Salmon

Journal:

Mechanisms of Ageing and Development

Année:

2001

Langue:

english

Fichier:

PDF, 75 KB

english, 2001

48

Disproportionate lymphoid cell subsets in thalassaemia major: the relative contributions of transfusion and splenectomy

Robert W. Grady, Arne N. Akbar, Patricia J. Giardina, Margaret W. Hilgartner, Maria de Sousa

Journal:

British Journal of Haematology

Année:

1985

Langue:

english

Fichier:

PDF, 746 KB

english, 1985

49

Variation of human natural killer cell phenotypes with age: Identification of a unique KLRG1-negative subset

Richard P.G. Hayhoe, Sian M. Henson, Arne N. Akbar, Donald B. Palmer

Journal:

Human Immunology

Année:

2010

Langue:

english

Fichier:

PDF, 891 KB

english, 2010

50

Telomere erosion: a new link between HLA DR4 and rheumatoid arthritis?

Mike Salmon, Arne N Akbar

Journal:

Trends in Immunology

Année:

2004

Langue:

english

Fichier:

PDF, 75 KB

english, 2004